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Medical Definitions:

What is Glanzmann's Thrombasthenia?
From Wikipedia, the free encyclopedia:

Glanzmann's thrombasthenia is an extremely rare, autosomal recessive disorder of the blood, in which the platelets lack GPIIb/IIIa. Hence, no fibrinogen bridging can occur, and bleeding time is significantly prolonged.   more


Glanzmann's Thrombasthenia (GT) can be life-threatening. It is caused by a deficiency of a protein on the surface of the platelet, called Glycoprotein IIb/IIIa. As a result, platelets fail to form a plug at the site of an injury.

Like Bernard-Soulier Syndrome, children experience bruising, nose bleeds and bleeding in the mouth and gums.

Women may experience heavy or prolonged menstrual bleeding (menorrhagia) and bleeding at the time of childbirth.

Blood tests show:

  • that bleeding time is much longer than normal
  • that the platelets do not clump together at all (platelet aggregation is absent).
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